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Total 21775 results found since Jan 2013.

MicroRNA-Mediated Therapy Modulating Blood-Brain Barrier Disruption Improves Vascular Cognitive Impairment.
CONCLUSIONS: We here provide the first evidence that the TNFα-miR-501-3p-ZO-1 axis plays an important role in the pathogenesis of cerebral hypoperfusion-induced working memory deficits and white matter lesions, as a result of blood-brain barrier breakdown via tight junction disruption. Therapeutic manipulation of miR-501-3p holds promise for limiting vascular cognitive impairment progression. PMID: 29650692 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 12, 2018 Category: Cardiology Authors: Toyama K, Spin JM, Deng AC, Huang TT, Wei K, Wagenhäuser MU, Yoshino T, Nguyen H, Mulorz J, Kundu S, Raaz U, Adam M, Schellinger IN, Jagger A, Tsao PS Tags: Arterioscler Thromb Vasc Biol Source Type: research

Metastatic breast carcinoma induces vascular endothelial dysfunction in Balb-c mice: Role of the tumor necrosis factor-α and NADPH oxidase.
In this study, highly metastatic breast carcinoma cells which was derived from liver or brain metastasis of 4T1 murine breast carcinoma (4TLM and 4TBM, respectively), and 67NR cells which is tumorogenic but non-metastatic cells were used. Female Balb-c mice 8-10weeks old were divided into following groups: (1) Control, (2) injected with 67NR, (3) injected with 4TLM, and (4) injected with 4TBM orthotopically. Thoracic aorta was removed 23-25days after injection of tumor cells. Isometric tension studies were performed in response to potassium chloride (KCl), phenylephrine (Phe), acetylcholine (ACh, an endothelium-dependent v...
Source: Vascular Pharmacology - August 7, 2013 Category: Drugs & Pharmacology Authors: Dalaklioglu S, Tasatargil A, Kale S, Gamzetanriover, Dilmac S, Erin N Tags: Vascul Pharmacol Source Type: research

Angiotensin-(1-7) Counteracts the Effects of Ang II on Vascular Smooth Muscle Cells, Vascular Remodeling and Hemorrhagic Stroke: Role of the NFкB Inflammatory Pathway.
In conclusion, Ang-(1-7) counteracts the effects of Ang II on ICH via modulating NFκB inflammation pathway in HBVSMCs and cerebral microvessels. PMID: 26264508 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - August 8, 2015 Category: Drugs & Pharmacology Authors: Bihl JC, Zhang C, Zhao Y, Xiao X, Ma X, Chen Y, Chen S, Zhao B, Chen Y Tags: Vascul Pharmacol Source Type: research

Zinc finger protein 191 deficiency attenuates vascular smooth muscle cell proliferation, migration, and intimal hyperplasia after endovascular arterial injury
Objective: Restenosis engenders surgical vascular intervention failure. Zinc finger protein 191 (ZFP191) is a novel member of the SCAN domain family of Krüppel-like zinc finger transcription factors. Previous work reveals that ZFP191 is a pleiotropic factor that plays important roles in hematopoiesis, brain development, and tumor growth. Here, we sought to determine whether intimal hyperplasia was affected by the activity of ZFP191 and to investigate the molecular mechanisms that may underpin the process.Methods: Intimal hyperplasia was induced by guidewire injury in mouse femoral arteries. The arteries were harvested for...
Source: Journal of Vascular Surgery - June 6, 2013 Category: Surgery Authors: Lei Lv, Jiwei Zhang, Peng Wang, Qiurong Meng, Wei Liang, Lan Zhang Tags: Basic research studies Source Type: research

Adjunctive Techniques for Large Carotid Body Tumors Percutaneous Embolization, TCD Monitoring
Carotid body tumors are amongst the most vascular tumors encountered. Many surgeons opt for transarterial embolization using glue, Onyx, or PVA particles for large tumors. Generally, the tumoral blood supply arises from the external carotid branches. However, this circulation is very variable, and nontarget organ embolization, especially the brain, is a major concern. In the case described, the principle feeding vessels derived from both the external carotid branches and from a very large ipsilateral vertebral artery.
Source: Journal of Vascular Surgery - December 22, 2015 Category: Surgery Authors: Odeaa Al Jabbari, Walid Abu Saleh, Orlando Diaz, Alan Lumsden Tags: Abstract from the 2016 Southern Association for Vascular Surgery Annual Meeting Source Type: research

The Search for the Elusive Elixir of Life
By TOM EMERICK Here’s the executive summary: Most disease and health spending is age-related. As we age we get infirmities ranging from dementia to cancer to vascular disease. Nothing can prevent aging. Period. For millennia mankind has been been on a futile search to prevent aging. Search for the Elusive Elixir of Life For 3500 or more years mankind has been searching for the mythological Elixir of Life, the fountain of youth, the philosophers stone, pool of nectar, etc, that will defeat aging and extend life, if not achieve immortality. According to Wiki, “The elixir of life, also known as the elixir of immortality a...
Source: The Health Care Blog - February 4, 2016 Category: Consumer Health News Authors: Simon Nath Tags: THCB Tom Emerick Source Type: blogs

Vascular Anomalies of Posterior Fossa and Their Implications
Abstract: Posterior fossa houses very vital and sensitive structures namely midbrain, pons, medulla, and cerebellum. These structures are irrigated by vertebral, posterior inferior cerebellar, anterior inferior cerebellar, and superior cerebellar arteries. Parts of brain located in posterior fossa control important parts of body so any variation pertaining to stenosis, atresia, hypoplasia, fenestration, agenesis, and duplication in the arteries supplying these parts alter the irrigation pattern culminating into various morbid and mortal neurologic disorders. Therefore, a sound understanding and thorough knowledge of poster...
Source: Journal of Craniofacial Surgery - November 1, 2017 Category: Surgery Tags: Anatomical Studies Source Type: research

Brain-related complications of COVID-19 and the role of FDG-PET in detecting vascular and non-vascular defects throughout the body
Conclusions FDG-PET can characterize the extent of systemic disease in COVID-19 patients and provide value in the early identification of complications that may make patients more susceptible to the harmful respiratory and systemic side effects of COVID-19. Severe neurological ramifications of COVID-19 have been noted such as the increased prevalence of acute cerebrovascular incidents. In these contexts, emerging literature has proven that the use of FDG-PET can be useful in monitoring the neurological manifestations the COVID-19 virus.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Rigney, G., Ayubcha, C., Werner, T., Revheim, M.-E., Alavi, A. Tags: Neurosciences Source Type: research

Patient-reported outcome and cognitive measures to be used in vascular and brain tumor surgery: proposal for a minimum set
ConclusionThe identification of common outcome measures is the first step toward a shared data collection improving the quality and comparability of future studies.
Source: Neurological Sciences - June 2, 2022 Category: Neurology Source Type: research

Non-invasive through-skull brain vascular imaging and small tumor diagnosis based on NIR-II emissive lanthanide nanoprobes beyond 1500  nm.
Non-invasive through-skull brain vascular imaging and small tumor diagnosis based on NIR-II emissive lanthanide nanoprobes beyond 1500 nm. Biomaterials. 2018 Apr 17;171:153-163 Authors: Xue Z, Zeng S, Hao J Abstract Optical bioimaging by using the new short-wavelength infrared window (SWIR, also named as NIR-II, 1000-1700 nm) is emerged as a next generation imaging technique for disease diagnosis owing to the unprecedented improvements in imaging sensitivity and spatial resolution. However, it is challenging to search new imaging agents with highly biocompatible and bright narrow-band emission loc...
Source: Biomaterials - April 17, 2018 Category: Materials Science Authors: Xue Z, Zeng S, Hao J Tags: Biomaterials Source Type: research

Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma
Pathol Oncol Res. 2021 Nov 19;27:1609997. doi: 10.3389/pore.2021.1609997. eCollection 2021.ABSTRACTGlioblastoma (GBM) is the most aggressive type of brain tumor. Microvascular proliferation and abnormal vasculature are the hallmarks of the GBM, aggravating disease progression and increasing patient morbidity. Here, we uncovered a key role of ETS1 on vascular abnormality in glioblastoma. ETS1 was upregulated in endothelial cells from human tumors compared to endothelial cells from paired control brain tissue. Knockdown of Ets1 in mouse brain endothelial cells inhibited cell migration and proliferation, and suppressed expres...
Source: Pathology Oncology Research - December 6, 2021 Category: Pathology Authors: Jiefu Tang Yaling Li Boxuan Liu Wei Liang Sanbao Hu Meilian Shi Jie Zeng Mingzhen Li Minjiang Huang Source Type: research